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4 years agoGetting cancer is one of the scariest things a person might have and it doesn't only affect the person diagnosed but in addition individuals around that person as well. Cancer is definitely an incredibly deadly disease with several different types. It's challenging to find someone in the current world today who has not known a person who has or has had cancer. Due to this, millions of dollars are spent every year on cancer research to find out more about this deadly disease as well as to identify new effective treatments and cures for it.

The basis of such research is to identify the kinds of cancer, diagnose cancer in patients, and to find ways to stop, treat and cure the disease. You'll find various ways that cancer is researched. These ways include epidemiology and molecular bioscience, which is then employed in clinical trials to compare and evaluate the different treatments.

The various kinds of treatments that will be being researched are chemotherapy, radiation therapy, gene therapy, finding vaccines, targeted therapy and ways to raise the immune system. Anti-cancer vaccination research is done deals with exposing extracted tumors cells to UV light for a 24-hour period and then injecting them back in to the organism. This approach has also been successful on rats.

On the other hand, researches of this deadly disease has had its share of issues and is still battling many of them. The main issue it faces is funding. Most of the funding comes from donations, so people and different organizations have to go out and acquire funding from the public. Stem cell research has also stirred up a whole lot of controversy basically halting any current testing in this field. Another controversial topic with cancer research will be the clinical trials and the usage of animals and human beings.

As mentioned earlier, funding is just one of the most important parts of keeping such researches alive. There are plenty of organizations out there that can be doing their part to raise money for research. Several of these organizations include; The American Cancer Society, Institute of Cancer Research, Ludwig Institute for Cancer Research, United Devices Cancer Research Project, Friends of Cancer Research and the Walker Cancer Research Institute. This is just a short number of some of the organizations, but rest assured that there are plenty more out there.

Many volunteers world-wide commit themselves to raising funds for cancer research and cancer charities. Many hundreds of thousands more work in the industry as carers, or researching, prescribing, identifying and manufacturing drugs. Huge companies spend fortunes on cancer research. After so long and a lot of billions spent what exactly has cancer research revealed?

There are already regular breakthroughs in our comprehension of cancer, but little progress in its treatment. Modern research into cancer began within the 1940's and 50's when scientists isolated substances that killed cancer cells growing in a petri dish, or leukaemia cells in laboratory mice. Early successes in chemotherapy set the pace and received much media exposure, despite the fact that they only applied to 5% of cancer treatments at most.

Serving humanity by solving its major diseases has a celebrity status, there's a lot of kudos and an air of Hollywood linked to such things. Cancer research is high profile activity and every now and after that a scientific treatment is discovered that gains wide recognition, for example the HPV-16 trial, but it only applies itself to the treatment of a small number of cancers. Mass-media hype is a part of the problem of how we see cancer. Early discoveries setup an expectation that there was a cure-all treatment, a 'magic bullet' that will make its discoverer famous by curing cancer around the globe. The idea stems in part from aspirin, the original bullet that magically finds its way to the anguish and diminishes it.

Within the 1950's and 60's huge and expensive research projects were setup to test every known substance to find out if view it effected cancer cells. You could remember the discovery of the Madagascar Periwinkle (Catharansus Roseus), which revealed alkaloids (vinblastine and vincristine) that will be still used in chemotherapy today. Taxol, a remedy for ovarian and cancer of the breast originally came from the Pacific Yew tree. A remedy for testicular cancer and small-cell lung cancer called 'Etoposide' was derived from the May apple. In 'Plants Used Against Cancer' by Jonathan Hartwell over three thousand plants are identified from medical and folklore sources for the treatment of cancer, about 50% of that have been shown to have some impact on cancer cells in a test tube.

When these plants are made into synthetic drugs, single chemicals are isolated as well as the rest of the plant can be thrown away. The medicinally active molecules are extracted from the plant and modified until they're chemically unique. Then the compound is patented, given a brand name and tested.

Within the first phase it will generally be tested on animals, the other phase will decide dosage levels as well as in phase 3 it is tested on people. By the time it's approved through the Federal Drugs Authority (in U.S.A.) or perhaps the Medicines and Healthcare Products Regulation Agency (M.H.R.A.) in Britain, the development costs for a brand new drug can reach five hundred million dollars, which eventually has to be recouped from the consumer.

In addition to 'treatment directed' research for example finding chemicals that effect cancer cells, basic research continues apace, into differences between normal and cancerous cells. Within the last thirty years this research has revealed much about our nature, but still no cure. Here are some current strands of scientific research into cancer.

Antibody-guided therapy: this really is the original 'magic bullet'. Cancer researchers use monoclonal antibodies to carry poisons directly to the cancer cells without harming others.

Chronobiology: much of what happens in our bodies is governed by cycles, from the female monthly cycle to the cycles of brainwaves. Human health depends on interacting cycles geared to acts of perception, breathing, reproduction and renewal. Chronobiology analyses these cycles in regards to different times, such as day and night. Hormones, including stress and growth hormones, have their own cycles. For example they could be at their highest activity in the morning and quieter during the night. Cancer cells seem to no longer obey the exact same cycle rates as normal cells.

Anti-telomerase: one part of a cell, called the telomerase, governs the life cycle of a cell and just how often times it may multiply. Some cancer cells escape this control and can also raise the number of times they divide, becoming 'immortal'. Researchers hope to gain control over cancer cells by stopping the action of telomerase.

Anti-angiogenesis: secondary tumours (metastasis) can persuade the cells around them to grow new blood vessels to feed the tumours, supplying oxygen and nutrients for the growing cancer. This process is called angiogenesis and research here is finding ways to stop the signals to normal cells that start the process.

Anti-adhesion molecules: Cancer cells form into clumps, unlike those in a petri dish which form into a flatter arrangement. When you will find clumps of cells they appear to possess a quality that resists treatment. This strand of research looks at ways that can stop the cells clumping together, by dissolving the clumps for more effective treatment.

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